Dr. Krebs suggests that over a period of time a total dosage in excess of 300 grams is the average in controlling a moderate cancer crisis. The time needed to develop the maximum response is four months to over a year. If good response is obtained within the first three weeks, the dosage may be reduced or the clinical schedule changed to suit the convenience of the patient.

A severe cancer crisis brought under control may be maintained in a quiescent state by the oral administration of 1 gram of Vitamin B-17 daily. However some patients claim to feel "better" or "safer" with a 1.5 to 2.0 grams of 13-17 daily. Such dosage is determined by the patient's sense of well being, gain in strength, increased appetite, weight gain, and psychological improvement with reduction of anxiety and nervousness, with exhibition of a more nearly normal degree of optimism and interest in his environment.

Abnormal situations, stress or ill health of any kind have been known to be followed by a renewed outbreak or progression of the cancer process in some patients. The attending physician should be aware of these possibilities with patients in whom the cancer is under control. When a cancer crisis has been successfully controlled for more than two years, with patient showing good objective responses in weight gain, increased strength, return to a more nearly normal state of activity and vigour, with negative CGH urine tests, and with an improvement in x-rays or other objective evidence, the maintenance dose may be reduced to dietary levels of vitamin B17 of at least 500 milligrams per day.
 

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